In addition to your doctor's prescribed regimen for heat sensitive skin, we believe Psoria Gold® curcumin gel may aid in slowing down the production of the cell stimulants and growth factors which contribute to the unwanted appearance of heat or laser exposed skin. Psoria-Gold® does not replace your doctor's prescribed skin regimen.
Curcumin Gel may be used on affected areas to reduce the appearance of Heat and Light exposed skin.
Ultraviolet light exposure, whether the result of excessive sunlight exposure or exposure to tanning salons, may cause both acute and chronic damage to the skin through both ultraviolet A (UVA) and ultraviolet B (UVB) radiation. Acute sunburn, usually due to UVB exposure, may resemble a burn, with redness, pain and blistering. Chronic sun exposure, on the other hand, produces photo-aging as shown by thinning of the skin, skin fragility, scaling and pigmentary changes, as well as potential cancer formation, as shown by precancers, such as actinic keratoses, and cancers, such as melanomas, squamous cell carcinomas and basal cell carcinomas.
Injurious processes including burns and surgical trauma trigger wound healing processes through activation of transcription activators, such as nuclear factor kappa B (NF-kB). NF-kB is a family of related dimers, which bind to a common sequence on the DNA, the kB site. In the non-activated state these dimers (p50/p65) are located in the cytoplasm. When activated by injurious stimuli, the activated p50/p65 dimers translocate to the nucleus, where they binds to the DNA, resulting in the transcription of over 200 genes involved in the processes of wound healing.
Inhibition of Side Effects from Light and Heat Exposure with Curcumin Gel:
Curcumin, the active ingredient in turmeric, is a potent inhibitor of NF-kB activation. The process of activating NF-kB dimers in the cytoplasm involves the removal of an inhibitory protein (IkBα) by phosphorylation of its kinase (IkBα) kinase. This is achieved through phosphorylation of IkBα kinase at its serine/threonine sites by phosphorylase kinase (PhK). Curcumin gel, a potent inhibitor of PhK and inducer of damaged cell apotosis (Heng MCY. Curcumin in Cosmetics: Biochemical Basis for
Skin Repair with Use of Topical Curcumin. Cosmeceuticals and Active Cosmetics 2015;3:31-46), may thus be used as an anti-scarring topical agent, through inhibition of NF-kB-dependent inflammatory processes, including the secretion of TGFβ, responsible for scarring following light and heat induced injury.
First Response Protocol:
First Response Maintenance Protocol:
Anti-Photoaging and Anti-Carcinogenic Therapy
"Curcumin targeted signaling pathways: Basis for anti-photoaging and anti-carginogenic therapy; Protocols for work-up and anti-aging treatment for photodamaged skin"Antiaging Therapeutics, Vol X, 151-160 and 319-320. American Academy of Anti-Aging Medicine 2008.
Wound Healing: Perfect Regeneration
"Wound Healing in Adult Skin: Aiming for Perfect Regeneration" International Journal of Dermatology (2011) 50, 1058–1066. MCY Heng.
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