In the case of skin that has abnormally red and scaly symptoms, studies have shown an increased presence of the enzyme, Phosphorylase Kinase (PhK), as a result of a defective gene on the distal end of the 17th chromosome (Heng MCY et al. Br J Dermatol 1994; 130:298-306). The persistently high levels of the enzyme, PhK, in the skin result in rapid epidermal turnover leading to defective barrier function. If the epidermal turnover is too rapid, the barrier function is compromised, and sheds as much as every 4-6 days, as opposed to every 60 days in normal skin. In addition, skin becomes permeable to allergens and bacteria, leading to inflammation and infection.
We believe Psoria-Gold® curcumin gel is effective because it aids in slowing down the energy supply to the rapidly dividing cells which result in red, scaly, skin symptoms. With the adjunctive skin regimen and therapies prescribed by your doctor, curcumin gel may help to improve the appearance of red, scaly, and itchy skin.
Curcumin gel should be used until the skin appearance returns completely to normal (no redness, scaling or itching), as re-inflammation is less likely to recur when the skin regains its health. This may take 2-3 months for redness and scaling of the scalp, trunk, face, arms and legs. However, in the palms and soles, which have a much thicker skin barrier (up to 200 cell layer), or in areas of thicker skin, this may take 6-12 months.
RECOMMENDED PRODUCT: We recommend either Psoria Gold® CLASSIC Regular or CLASSIC Ultra formulas.
DIRECTIONS: If the skin is thick and scaly, first apply rubbing alcohol and massage Psoria-Gold® into the wet alcohol. This ensures better absorption. Make sure Psoria-Gold® is massaged thoroughly underneath the thick scales. Treat small areas at any one time in order to ensure that the alcohol is still wet before applying Psoria-Gold®. However, if the alcohol dries out the skin too much, you may skip this step, and apply Psoria-Gold® directly to the skin.
Since curcumin gel should be used as adjunctive therapy in red, scaly skin, continue your steroid preparations and additional therapy prescribed by your doctor during the day. Since creams/ointments prevent Psoria-Gold® from being absorbed, you should first wash off any creams and ointments before use. Continue using your usual creams/ointments during the day and Psoria-Gold® in the evenings until it is completely resolved.
Psoria-Gold® does not replace your regular treatment.
To maximize sterility, use a cotton swab to transfer gel onto a clean surface. USE A FRESH COTTON SWAB TIP, AND DO NOT REDIP PREVIOUSLY USED SWAB INTO THE JAR TO AVOID TRANSFERRING BACTERIA FROM THE SKIN TO THE JAR. For the hands, reapply ointments after hand washing if skin is too dry.
You must identify and remove the injury factors that aggravate your red, scaly skin. You should SEE YOUR DOCTOR for this. Aggravating factors include, but are limited to: (1) Bacterial superinfection (Staphylococcus aureus) if skin is red and itchy; (2) Streptococcus infection- ears, throat, groin, perianal; (3) Pityosporum ovale in scalp; (4) Contact allergies - elastic, leather, black dyes, neoprene glues (shoes), nickel; (5) lactose intolerance; (6) zinc deficiency.
CAUTION: Avoid contact with eyes and mucous membranes.For external and cosmetic use only. Keep away from open flame. Not for use on open wounds. Replace cap to avoid drying of gel. Keep out of reach from children.
Elevated Phosphorylase Kinase and Psoriasis
"Elevated phosphorylase kinase activity in psoriatic epidermis: correlation with increased phosphorylation and psoriatic activity" British Journal of Dermatology (1994) 130, 298-306. MCY Heng, MK Song, MK Heng.
Drug-Induced Suppression for Psoriasis
"Drug induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological, and immunohistochemical parameters" British Journal of Dermatology (2000) 143, 937-949. MCY Heng, MK Song, J Harker, MK Heng.
Proof of Concept Study with 638 Patients
"Results of Combining Phosphorylase Kinase Inhibition with Removal of Precipitating Factors in Large Cohort of Psoriatic Patients: A Proof of Concept Study" Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 79-94. MCY Heng, Judith Harker, MK Heng..
"Phosphorylase kinase (ph-K) is a unique enzyme released within 5 minutes following skin injury, and serves as a catalyst for the processes that result in the subsequent activation of over 200 genes responsible for inflammation, cell damage and scarring. In the case of Psoriasis, due to a genetic inability to "switch off" phosphorylase kinase activity, the psoriatic patient continues to exhibit continual cell proliferation which results in symptoms such as flaking, plaque development, lesions which do not heal, and a compromised skin barrier.
The usual treatment of immunosuppressants and/or steroids (both oral and topical) does not suppress phosphorylase kinase by itself, and does not kill off the Ki-67+ epidermal cells that cause the skin to grow rapidly, as in the case of psoriasis. The disease often recurs when treatment is stopped. In addition, there may be unwanted side effects. In this website, we detail my standard regimen of treatment as an alternative without the use of immunosuppressants.
My patients usually are 65-70% improved in 4 weeks, 85% improved in 8 weeks, 95% in 3 months, and almost totally clear in 4-6 months. The palms and soles take longer because they have 200 layers of stratum corneum instead of 10 layers of stratum corneum to replace. It takes 60 days to replace the first layer of stratum corneum.
As long as the precipitating factors are treated and removed, it is my experience that if patients use the protocol in this website correctly, and are treated until the Ki-67+ cells are normalized, the disease does not recur after the treatment is tapered off.
These are my suggested methods of treatment based on over 35 years of research and practice. See your doctor before applying any psoriasis treatment methods. Please let me know if I may be of further help."
For questions about my regimen, please view PsoriaInfo.com:
-Madalene C.Y. Heng MD, FRACP, FACD, FAAD
Clinical Professor of Medicine, Dermatology
David Geffen School of Medicine, UCLA
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